| Thursday, October 24 | NET YPP (Away) | NET YPP (Home) | NET YPP Differential (Home Team) | TIME (ET) | NAT TV | Spread (home team) | ||
| #16 SMU | Houston | 1.3 | -0.8 | -2.1 | 7:30 PM | ESPN | +13.5 | |
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Friday, October 25 |
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| USC | Colorado | 0.7 | -1.2 | -1.9 | 9:00 PM | ESPN2 | +13.5 | |
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Saturday, October 26 |
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| #13 Wisconsin | #3 Ohio State | 2.8 | 3.8 | 1 | 12:00 PM | FOX | -14 | |
| #5 Oklahoma | Kansas State | 4.6 | -0.6 | -5.2 | 12:00 PM | ABC | +23.5 | |
| #20 Iowa | Northwestern | 0.8 | -1.5 | -2.3 | 12:00 PM | ESPN2 | +10.5 | |
| #21 Appalachian State | South Alabama | 0.9 | -1.8 | -2.7 | 12:00 PM | ESPNU | +25 | |
| Miami | Pittsburgh | 0.7 | 0.4 | -0.3 | 12:00 PM | ESPN | -6 | |
| San Jose State | Army | -0.1 | -0.4 | -0.3 | 12:00 PM | CBSSN | -9 | |
| Mississippi State | Texas A&M | -0.7 | -0.1 | 0.6 | 12:00 PM | SECN | -11.5 | |
| Illinois | Purdue | -1 | -0.6 | 0.4 | 12:00 PM | BTN | -10 | |
| Liberty | Rutgers | -0.5 | -1.9 | -1.4 | 12:00 PM | BTN | +7.5 | |
| Bowling Green | Western Michigan | -2.7 | 0.3 | 3 | 12:00 PM | ESPN3 | -27.5 | |
| Southern Mississippi | Rice | -0.2 | -1.8 | -1.6 | 1:00 PM | ESPN+ | +10 | |
| Nevada | Wyoming | -1.8 | 0.6 | 2.4 | 2:00 PM | -14 | ||
| Ohio | Ball State | -0.4 | 0.2 | 0.6 | 2:00 PM | ESPN+ | -3 | |
| Western Kentucky | Marshall | 0.4 | 0.3 | -0.1 | 2:30 PM | -5.5 | ||
| New Mexico State | Georgia Southern | -1.8 | -1.6 | 0.2 | 3:00 PM | ESPN3 | -14.5 | |
| #9 Auburn | #2 LSU | 1.5 | 2.9 | 1.4 | 3:30 PM | CBS | -10 | |
| #6 Penn State | Michigan State | 2 | 0.6 | -1.4 | 3:30 PM | ABC | +6.5 | |
| #15 Texas | TCU | -0.3 | 0.6 | 0.9 | 3:30 PM | FOX | +1 | |
| Maryland | #17 Minnesota | -0.7 | 1.9 | 2.6 | 3:30 PM | ESPN | -16 | |
| Oklahoma State | #23 Iowa State | 0.1 | 2.7 | 2.6 | 3:30 PM | FS1 | -10.5 | |
| UConn | UMass | -2.4 | -3.4 | -1 | 3:30 PM | +10 | ||
| North Texas | Charlotte | 0 | -0.2 | -0.2 | 3:30 PM | ESPN+ | +3.5 | |
| Florida International | Middle Tennessee | 0.4 | -1.2 | -1.6 | 3:30 PM | NFL | +2.5 | |
| Florida Atlantic | Old Dominion | -1.6 | -2 | -0.4 | 3:30 PM | ESPN+ | +13.5 | |
| Syracuse | Florida State | -1.6 | -0.1 | 1.5 | 3:30 PM | ESPN2 | -9.5 | |
| Virginia | Louisville | 0.3 | -0.6 | -0.9 | 3:30 PM | ACCN | +3.5 | |
| Arizona | Stanford | -0.3 | -1.2 | -0.9 | 3:30 PM | PAC12 | +1 | |
| Indiana | Nebraska | 1.1 | 0.2 | -0.9 | 3:30 PM | BTN | -1 | |
| Tulane | Navy | 1.2 | 1.7 | 0.5 | 3:30 PM | CBSSN | -3 | |
| Central Michigan | Buffalo | 0.4 | -0.1 | -0.5 | 3:30 PM | ESPN+ | -2.5 | |
| Eastern Michigan | Toledo | -0.7 | -1.2 | -0.5 | 3:30 PM | ESPN+ | -4 | |
| Miami (OH) | Kent State | -1.8 | -1 | 0.8 | 3:30 PM | ESPN+ | -1 | |
| Akron | Northern Illinois | -1.5 | -1 | 0.5 | 3:30 PM | ESPN3 | -23.5 | |
| South Florida | East Carolina | -0.7 | -1.3 | -0.6 | 3:45 PM | ESPNU | +2 | |
| Hawai’i | New Mexico | -0.1 | -0.8 | -0.7 | 4:00 PM | +10 | ||
| Duke | North Carolina | -0.2 | -0.2 | 0 | 4:00 PM | ACCNX | -3.5 | |
| South Carolina | Tennessee | -0.8 | -0.6 | 0.2 | 4:00 PM | SECN | +4.5 | |
| Arkansas | #1 Alabama | -0.8 | 3.2 | 4 | 7:00 PM | ESPN | -32 | |
| Texas Tech | Kansas | -1 | 0.1 | 1.1 | 7:00 PM | FS1 | +4 | |
| UCF | Temple | 1.9 | 0 | -1.9 | 7:00 PM | ESPN2 | +10 | |
| Memphis | Tulsa | 1.8 | -0.7 | -2.5 | 7:00 PM | CBSSN | +10.5 | |
| Texas State | Arkansas State | -1.5 | -0.5 | 1 | 7:00 PM | ESPN+ | -11.5 | |
| Troy | Georgia State | -0.9 | -0.8 | 0.1 | 7:00 PM | ESPN+ | -1 | |
| Boston College | #4 Clemson | -0.1 | 3.1 | 3.2 | 7:30 PM | ACCN | -33.5 | |
| #8 Notre Dame | #19 Michigan | 2 | 1.3 | -0.7 | 7:30 PM | ABC | +1 | |
| #24 Arizona State | UCLA | 0.3 | -1 | -1.3 | 7:30 PM | PAC12 | +3.5 | |
| Colorado State | Fresno State | -0.2 | 0.8 | 1 | 7:30 PM | ESPNU | -14.5 | |
| Missouri | Kentucky | 1.1 | -0.4 | -1.5 | 7:30 PM | SECN | +10 | |
| Louisiana Tech | UTEP | 1.3 | -2.4 | -3.7 | 8:00 PM | ESPN3 | +20.5 | |
| California | #12 Utah | -0.6 | 1.8 | 2.4 | 10:00 PM | FS1 | -21.5 | |
| Utah State | Air Force | 0.2 | 0.7 | 0.5 | 10:15 PM | ESPN2 | -3.5 | |
| Washington State | #11 Oregon | 0.8 | 2.1 | 1.3 | 10:30 PM | ESPN | -14 | |
| San Diego State | UNLV | 0.1 | -2.2 | -2.3 | 10:30 PM | CBSSN | +13.5 |
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